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Neuroscience Information Framework (NIF) Standard Ontology
| Preferred Name | morphine | |
| Synonyms |
Morphina Morfina hydrochloride (-)-Morphine Morphine Forte Statex Morphine Sulfate Depodur Heroine hydrochloride Meconium Diacetylmorphine hydrochloride Morphitec Heroin hydrochloride Morphine Extra-Forte MSIR Morphium Roxanol UD Morphine hydrochloride Kadian Statex Drops Morphine H M-Eslon Epimorph (-)-Heroin hydrochloride Duramorph PF Roxanol 100 Rescudose Moscontin Nepenthe Diamorphine hydrochloride Ms Contin Ospalivina Avinza D-(-)-Morphine Apokyn Duromorph RMS Uniserts O'-Diacetylmorphine Astramorph PF Oramorph SR Morphinum Roxanol Morphinism Dulcontin l-Morphine (-)-morphine Morphia morphinum (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL morphium morfina (5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol Morphin (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol Morphine |
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| Definitions |
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. (PubChem) Pharmacology: Morphine is a narcotic pain management agent indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Morphine interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, morphine exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Morphine appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers. Mechanism of action: The precise mechanism of the analgesic action of morphine is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the expression of analgesic effects. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. Drug type: Approved. Investigational. Small Molecule. Drug category: Analgesics. Analgesics, Opioid. Narcotics. Opiate Agonists A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy). Street names: O, M, S, MS/L, MS/S, P, OMS Concentrate |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_17303 |
|
| comment |
Street names: O, M, S, MS/L, MS/S, P, OMS Concentrate
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|
| alternative label |
(-)-morphine Morphia morphinum (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL morphium morfina (5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol Morphin (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol Morphine
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|
| charge |
0
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|
| createdDate |
March 5, 2010
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|
| database_cross_reference |
PDBeChem:MOI PMID:15019787 PMID:17171884 PMID:20071451 KEGG:D08233 PMID:19371311 PMID:29368335 Beilstein:93704 PMID:23555556 CAS:57-27-2 MetaCyc:MORPHINE PMID:27815868 KNApSAcK:C00001889 Drug_Central:1845 Reaxys:93704 PMID:23927484 PMID:12593758 PMID:9231550 PDB:1Q0Y PMID:23292329 PMID:24306419 VSDB:2982 KEGG:C01516 PMID:17667569 PMID:27866460 PMID:23325235 PMID:23988259 Wikipedia:Morphine PMID:24096538 PMID:21061062 PMID:27735107 DrugBank:DB00295
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|
| definition |
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. (PubChem) Pharmacology: Morphine is a narcotic pain management agent indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Morphine interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, morphine exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Morphine appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers. Mechanism of action: The precise mechanism of the analgesic action of morphine is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the expression of analgesic effects. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. Drug type: Approved. Investigational. Small Molecule. Drug category: Analgesics. Analgesics, Opioid. Narcotics. Opiate Agonists A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy). Street names: O, M, S, MS/L, MS/S, P, OMS Concentrate
|
|
| formula |
C17H19NO3
|
|
| has characteristic |
http://uri.neuinfo.org/nif/nifstd/nlx_chem_090801 http://purl.obolibrary.org/obo/CHEBI_76924 http://purl.obolibrary.org/obo/CHEBI_176497 http://purl.obolibrary.org/obo/CHEBI_38867 http://purl.obolibrary.org/obo/CHEBI_35703 http://purl.obolibrary.org/obo/CHEBI_35620 http://purl.obolibrary.org/obo/CHEBI_55322 http://purl.obolibrary.org/obo/CHEBI_88188 |
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| has exact synonym |
17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol Morphine
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| has parent hydride | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_76924 http://purl.obolibrary.org/obo/CHEBI_176497 http://purl.obolibrary.org/obo/CHEBI_38867 http://purl.obolibrary.org/obo/CHEBI_35703 http://purl.obolibrary.org/obo/CHEBI_35620 http://purl.obolibrary.org/obo/CHEBI_55322 http://purl.obolibrary.org/obo/CHEBI_88188 |
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| has_alternative_id |
CHEBI:7001 CHEBI:44202 CHEBI:25419 CHEBI:14622
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| has_obo_namespace |
chebi_ontology
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|
| has_related_synonym |
(-)-morphine Morphia morphinum (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL morphium morfina (5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol Morphin (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol
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|
| hasExternalSource |
DB00295
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|
| hasStreetName |
OMS Concentrate MS/L S P O MS/S M
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|
| id |
CHEBI:17303
|
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| in_subset | ||
| inchi |
InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
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|
| inchikey |
BQJCRHHNABKAKU-KBQPJGBKSA-N
|
|
| is conjugate base of | ||
| label |
morphine
|
|
| mass |
285.33770
|
|
| modifiedDate |
May 21, 2010
|
|
| monoisotopicmass |
285.13649
|
|
| notation |
CHEBI:17303
|
|
| note |
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. (PubChem) Pharmacology: Morphine is a narcotic pain management agent indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Morphine interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, morphine exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Morphine appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers. Mechanism of action: The precise mechanism of the analgesic action of morphine is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the expression of analgesic effects. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. Drug type: Approved. Investigational. Small Molecule. Drug category: Analgesics. Analgesics, Opioid. Narcotics. Opiate Agonists A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy). Street names: O, M, S, MS/L, MS/S, P, OMS Concentrate
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|
| preferred label |
morphine
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| prefLabel |
morphine
|
|
| smiles |
[H][C@]12C=C[C@H](O)[C@@H]3Oc4c(O)ccc5C[C@H]1N(C)CC[C@@]23c45
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| synonym |
Morphina Morfina hydrochloride (-)-Morphine Morphine Forte Statex Morphine Sulfate Depodur Heroine hydrochloride Meconium Diacetylmorphine hydrochloride Morphitec Heroin hydrochloride Morphine Extra-Forte MSIR Morphium Roxanol UD Morphine hydrochloride Kadian Statex Drops Morphine H M-Eslon Epimorph (-)-Heroin hydrochloride Duramorph PF Roxanol 100 Rescudose Moscontin Nepenthe Diamorphine hydrochloride Ms Contin Ospalivina Avinza D-(-)-Morphine Apokyn Duromorph RMS Uniserts O'-Diacetylmorphine Astramorph PF Oramorph SR Morphinum Roxanol Morphinism Dulcontin l-Morphine
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|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_38164 http://uri.neuinfo.org/nif/nifstd/nlx_chem_1003011 |
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