loading...| Preferred Name | Prion Disease | |
| Synonyms |
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| Definitions |
A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES (MeSH). |
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| ID |
http://uri.neuinfo.org/nif/nifstd/birnlex_12686 |
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| createdDate |
2007-10-05 |
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| definingCitation |
Proc Natl Acad Sci USA 1998 Nov 10;95(23):13363-83 |
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| definition |
A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES (MeSH). |
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| editorial note | ||
| hasBirnlexCurator | ||
| hasCurationStatus | ||
| hasDefinitionSource | ||
| hasExternalSource | ||
| label |
Prion Disease |
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| MeshUid |
D017096 |
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| modifiedDate |
2007-10-05 |
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| nifID |
_8.3_2.8 |
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| note |
A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES (MeSH). |
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| preferred label |
Prion Disease |
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| putativeClassExtension |
Inherited Human Transmissible Spongiform Encephalopathy |
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| synonym |
Transmissible Dementia Transmissible Spongiform Encephalopathy Prion-Induced Disorder Prion Protein Disease |
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| usageNote |
MeSH includes qualified subtype limiting to humans |
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| subClassOf |