National Cancer Institute Thesaurus

Last uploaded: December 30, 2019
Preferred Name

Amitriptyline

Synonyms

amitriptyline

Amitriptyline

AMITRIPTYLINE

Definitions

A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62005

ALT_DEFINITION

A drug that is used to treat depression and may be given to treat anxiety, sleep disorders, and pain. It is also being studied in an oral or gel form in the treatment of nerve pain caused by chemotherapy. Amitriptyline is a type of tricyclic antidepressant.

CAS_Registry

50-48-6

CHEBI_ID

CHEBI:2666

Chemical_Formula

C20H23N

code

C62005

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity.

FDA_UNII_Code

1806D8D52K

FULL_SYN

amitriptyline

Amitriptyline

AMITRIPTYLINE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28819

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96201

label

Amitriptyline

Legacy_Concept_Name

Amitriptyline_Base

Preferred_Name

Amitriptyline

prefixIRI

ncit:C62005

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0002600

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94727

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http://scai.fraunhofer.de/MSOntology#Amitriptyline MSO LOOM
http://purl.bioontology.org/ontology/CSP/0780-6741 CRISP LOOM
http://purl.jp/bio/4/id/200906000783681540 IOBC LOOM
http://www.case.edu/EpSO.owl#Amitriptyline EPSO LOOM
http://purl.bioontology.org/ontology/NDDF/004600 NDDF LOOM
http://scdontology.h3abionet.org/ontology/SCDO_0004190 SCDO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004907 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_2666 ODNAE LOOM
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http://purl.obolibrary.org/obo/CHEBI_2666 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2666 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2666 CHEBI LOOM
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http://purl.obolibrary.org/obo/CHEBI_2666 CHEBI LOOM
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http://purl.bioontology.org/ontology/MESH/D000639 MESH LOOM
http://purl.bioontology.org/ontology/RCD/x01Aw RCD LOOM
http://purl.bioontology.org/ontology/RXNORM/704 RXNORM LOOM
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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.181.384.100 RH-MESH LOOM
http://www.limics.fr/ontologies/ontoparonmed#Laroxyl ONTOPARON LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Amitriptyline APAONTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.181.384.100 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004213 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004213 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004213 DMTO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372726002 SNOMEDCT LOOM
http://www.drugbank.ca/drugs/DB00321 FTC LOOM
http://stirdf.jst.go.jp/id/200907030405814109 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147702 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D000639 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1027 OCHV LOOM
http://scai.fraunhofer.de/AlzheimerOntology#amitriptyline ADO LOOM
http://www.co-ode.org/ontologies/galen#Amitriptyline GALEN LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0002600 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/LP14983-8 LOINC LOOM
http://www.gamuts.net/entity#amitriptyline GAMUTS LOOM
http://purl.bioontology.org/ontology/VANDF/4019607 VANDF LOOM
http://bmi.utah.edu/ontologies/peontology/C0002600 RAO LOOM
http://purl.bioontology.org/ontology/SNMI/C-62250 SNMI LOOM