National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Tofacitinib Citrate
Synonyms

Tofacitinib Citrate

CP-690,550-10

1-Piperidinepropanenitrile, 4-Methyl-3-(Methyl-7H-Pyrrolo(2,3-d)Pyrimidin-4-ylamino)-Beta-Oxo-, (3R,4R)-, 2-Hydroxy-1,2,3-Propanetricarboxylate (1:1)

Tasocitinib Citrate

TOFACITINIB CITRATE

Xeljanz

Definitions

The citrate salt form of tofacitinib, an orally bioavailable inhibitor of Janus kinases (JAK), with immunomodulatory and anti-inflammatory activities. Upon oral administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription (STAT) signaling pathway. This may decrease the production of pro-inflammatory cytokines, such as interleukin (IL)-6, -7, -15, -21, interferon-alpha (IFN-a) and -beta (IFN-b), and may prevent both an inflammatory response and the inflammation-induced damage caused by certain immunological diseases. JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis, immunity and inflammation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95801

CAS_Registry

540737-29-9

Chemical_Formula

C16H20N6O.C6H8O7

code

C95801

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The citrate salt form of tofacitinib, an orally bioavailable inhibitor of Janus kinases (JAK), with immunomodulatory and anti-inflammatory activities. Upon oral administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription (STAT) signaling pathway. This may decrease the production of pro-inflammatory cytokines, such as interleukin (IL)-6, -7, -15, -21, interferon-alpha (IFN-a) and -beta (IFN-b), and may prevent both an inflammatory response and the inflammation-induced damage caused by certain immunological diseases. JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis, immunity and inflammation.

FDA_UNII_Code

O1FF4DIV0D

FULL_SYN

Tofacitinib Citrate

CP-690,550-10

1-Piperidinepropanenitrile, 4-Methyl-3-(Methyl-7H-Pyrrolo(2,3-d)Pyrimidin-4-ylamino)-Beta-Oxo-, (3R,4R)-, 2-Hydroxy-1,2,3-Propanetricarboxylate (1:1)

Tasocitinib Citrate

TOFACITINIB CITRATE

Xeljanz

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95800

label

Tofacitinib Citrate

Preferred_Name

Tofacitinib Citrate

prefixIRI

Thesaurus:C95801

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C2715644

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C172200

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