Link to this page
National Cancer Institute Thesaurus
| Preferred Name | Warfarin | |
| Synonyms |
3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin Compound 42 WARF Compound 42 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin WARF compound 42 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone Co-Rax Rodex WARFARIN Warfarin warfarin |
|
| Definitions |
A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C945 |
|
| Accepted_Therapeutic_Use_For |
Pulmonary embolism and thromboembolic disorders, treatment and prophylaxis; Venous thrombosis, prophylaxis and treatment
|
|
| ALT_DEFINITION |
A vitamin K antagonist anticoagulant A drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners).
|
|
| CAS_Registry |
81-81-2
|
|
| CHEBI_ID |
CHEBI:10033
|
|
| Chemical_Formula |
C19H16O4
|
|
| code |
C945
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191406 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191670 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191405 |
|
| Contributing_Source |
ACC/AHA CTRP FDA HemOnc
|
|
| DEFINITION |
A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity.
|
|
| Display_Name |
Warfarin
|
|
| FDA_UNII_Code |
5Q7ZVV76EI
|
|
| FULL_SYN |
3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin Compound 42 WARF Compound 42 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin WARF compound 42 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone Co-Rax Rodex WARFARIN Warfarin warfarin
|
|
| Has_ACC-AHA_SARS2_Authorized_Value |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998 |
|
| Has_Salt_Form | ||
| label |
Warfarin
|
|
| Legacy Concept Name |
Warfarin
|
|
| NCI_Drug_Dictionary_ID |
39740
|
|
| NSC Number |
59813
|
|
| PDQ_Closed_Trial_Search_ID |
39740
|
|
| PDQ_Open_Trial_Search_ID |
39740
|
|
| Preferred_Name |
Warfarin
|
|
| prefixIRI |
Thesaurus:C945
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0043031
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |