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National Cancer Institute Thesaurus
| Preferred Name | Verapamil | |
| Synonyms |
alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile VERAPAMIL Verapamil |
|
| Definitions |
A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C928 |
|
| CAS_Registry |
52-53-9
|
|
| CHEBI_ID |
CHEBI:9948
|
|
| Chemical_Formula |
C27H38N2O4
|
|
| code |
C928
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC
|
|
| DEFINITION |
A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
|
|
| Display_Name |
Verapamil
|
|
| FDA_UNII_Code |
CJ0O37KU29
|
|
| FULL_SYN |
alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile VERAPAMIL Verapamil
|
|
| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Verapamil
|
|
| Legacy Concept Name |
Verapamil
|
|
| Maps_To |
Verapamil
|
|
| NCI_Drug_Dictionary_ID |
39730
|
|
| PDQ_Closed_Trial_Search_ID |
39730
|
|
| PDQ_Open_Trial_Search_ID |
39730
|
|
| Preferred_Name |
Verapamil
|
|
| prefixIRI |
Thesaurus:C928
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0042523
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| subClassOf |
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