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National Cancer Institute Thesaurus
| Preferred Name | Streptozocin | |
| Synonyms |
Streptozotocin 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose STREPTOZOCIN 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose streptozocin 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose Streptozocin STZ U 9889 U-9889 Zanosar |
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| Definitions |
A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C845 |
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| Accepted_Therapeutic_Use_For |
Carcinoid tumor and syndrome; Colorectal cancer, palliative; Hodgkin's disease; Metastatic islet cell carcinoma of the pancreas
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called alkylating agents.
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| CAS_Registry |
18883-66-4
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|
| CHEBI_ID |
CHEBI:9288
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|
| Chemical_Formula |
C8H15N3O7
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|
| code |
C845
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
FDA GDC HemOnc
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|
| DEFINITION |
A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. (NCI04)
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|
| FDA_UNII_Code |
5W494URQ81
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|
| FULL_SYN |
Streptozotocin 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose STREPTOZOCIN 2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose streptozocin 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose Streptozocin STZ U 9889 U-9889 Zanosar
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|
| Is_Value_For_GDC_Property | ||
| label |
Streptozocin
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|
| Legacy Concept Name |
Streptozocin
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|
| Maps_To |
Streptozocin
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|
| NCI_Drug_Dictionary_ID |
42831
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|
| NSC Number |
85998
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| PDQ_Closed_Trial_Search_ID |
42831
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| PDQ_Open_Trial_Search_ID |
42831
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|
| Preferred_Name |
Streptozocin
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|
| prefixIRI |
Thesaurus:C845
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0038432
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| subClassOf |
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