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National Cancer Institute Thesaurus
| Preferred Name | Spironolactone | |
| Synonyms |
Spironolactone 17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate SPIRONOLACTONE Aldactone SC 9420 SPL |
|
| Definitions |
A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities.Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C840 |
|
| CAS_Registry |
52-01-7
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|
| CHEBI_ID |
CHEBI:9241
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|
| Chemical_Formula |
C24H32O4S
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|
| code |
C840
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
|
|
| DEFINITION |
A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities.Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors.
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|
| Display_Name |
Spironolactone
|
|
| FDA_UNII_Code |
27O7W4T232
|
|
| FULL_SYN |
Spironolactone 17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate SPIRONOLACTONE Aldactone SC 9420 SPL
|
|
| label |
Spironolactone
|
|
| Legacy Concept Name |
Spironolactone
|
|
| NCI_Drug_Dictionary_ID |
39444
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|
| NSC Number |
150399
|
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| PDQ_Closed_Trial_Search_ID |
39444
|
|
| PDQ_Open_Trial_Search_ID |
39444
|
|
| Preferred_Name |
Spironolactone
|
|
| prefixIRI |
Thesaurus:C840
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0037982
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| subClassOf |
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