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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Prothrombin | |
| Synonyms |
Prothrombin EC 3.4.21.5 Coagulation Factor II F2 Factor II |
|
| Definitions |
Prothrombin (622 aa, ~70 kDa) is encoded by the human F2 gene. This protein plays a role in both coagulation and proteolysis of fibrinogen. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82854 |
|
| code |
C82854
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
|
| Contributing_Source |
CTRP
|
|
| DEFINITION |
Prothrombin (622 aa, ~70 kDa) is encoded by the human F2 gene. This protein plays a role in both coagulation and proteolysis of fibrinogen.
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|
| DesignNote |
Prothrombin protein can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain, thrombin heavy chain. (UniProt) Prior to secretion, prothrombin is modified to have gamma-carboxyglutamyl residues, resulting from the carboxylation of glutamyl residues by vitamin K-dependent gamma-carboxylase. These modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin. (UniProt) Prothrombin catalyzes the cleavage of Arg-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. (UniProt) Prothrombin activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. (UniProt)
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|
| Display_Name |
Prothrombin
|
|
| FULL_SYN |
Prothrombin EC 3.4.21.5 Coagulation Factor II F2 Factor II
|
|
| label |
Prothrombin
|
|
| Legacy Concept Name |
Prothrombin_Gene_Product
|
|
| NCI_META_CUI |
CL449006
|
|
| OMIM_Number |
176930
|
|
| Preferred_Name |
Prothrombin
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|
| prefixIRI |
Thesaurus:C82854
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme
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|
| Swiss_Prot |
P00734
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|
| subClassOf |
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