National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Dapagliflozin
Synonyms

D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-, Compd. with (2S)-1,2-propanediol, Hydrate (1:1:1)

DAPAGLIFLOZIN

Dapagliflozin

BMS-512148-05

Definitions

A selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. Dapagliflozin selectively and potently inhibits SGLT2 compared to SGLT1, which is the cotransporter of glucose in the gut.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78126

CAS_Registry

461432-26-8

Chemical_Formula

C21H25ClO6

code

C78126

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. Dapagliflozin selectively and potently inhibits SGLT2 compared to SGLT1, which is the cotransporter of glucose in the gut.

Display_Name

Dapagliflozin

FDA_UNII_Code

1ULL0QJ8UC

FULL_SYN

D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-, Compd. with (2S)-1,2-propanediol, Hydrate (1:1:1)

DAPAGLIFLOZIN

Dapagliflozin

BMS-512148-05

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C119006

label

Dapagliflozin

Legacy Concept Name

Dapagliflozin

NCI_Drug_Dictionary_ID

802820

PDQ_Closed_Trial_Search_ID

802820

PDQ_Open_Trial_Search_ID

802820

Preferred_Name

Dapagliflozin

prefixIRI

Thesaurus:C78126

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C2353951

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98083

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