National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

SGLT2 Inhibitor
Synonyms

SLC5A2 Inhibitor

SGLT2 Inhibitor

SGLT2 inhibitor
Definitions

Any inhibitor of the sodium-glucose co-transporter subtype 2 (SGLT2) with antihyperglycemic activity. By binding to and blocking SGLT2, these inhibitors suppress reabsorption of glucose in the proximal tubule within the kidneys and thereby enhancing urinary excretion of glucose. This eventually normalizes blood glucose levels. SGLT2, a transport system exclusively expressed in the proximal renal tubules, mediates about 90% of renal glucose reabsorption from tubular fluid.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98083
ALT_DEFINITION

SGLT2 inhibitors inhibit the sodium glucose cotransporter 2 in the kidney, and selected agents in this class have demonstrated benefit in HF, CKD, ASCVD, and diabetes.
code

C98083
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191670

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191405
Contributing_Source

ACC/AHA

CTRP
DEFINITION

Any inhibitor of the sodium-glucose co-transporter subtype 2 (SGLT2) with antihyperglycemic activity. By binding to and blocking SGLT2, these inhibitors suppress reabsorption of glucose in the proximal tubule within the kidneys and thereby enhancing urinary excretion of glucose. This eventually normalizes blood glucose levels. SGLT2, a transport system exclusively expressed in the proximal renal tubules, mediates about 90% of renal glucose reabsorption from tubular fluid.
Display_Name

SGLT2 Inhibitor
FULL_SYN

SLC5A2 Inhibitor

SGLT2 Inhibitor

SGLT2 inhibitor
Has_ACC-AHA_SARS2_Authorized_Value

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49488

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49487
Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C119006
label

SGLT2 Inhibitor
Preferred_Name

SGLT2 Inhibitor
prefixIRI

Thesaurus:C98083
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C3273807
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471
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