loading...| Preferred Name | Prednisolone | |
| Synonyms |
Lepi-Cortinolo Meticortelone 1,2-Dehydrohydrocortisone Delta-Cortef Di-Adreson-F Delta-Diona Kuhlprednon Delta1-dehydro-hydrocortisone Deltacortril Hostacortin H Predni-Coelin Cortisolone Deltidrosol Longiprednil prednisolone Delta-Phoricol Prednisolone Linola-H-Fett N Prednisolonum Deltasolone Prednicortelone Panafcortelone Metacortandralone Decaprednil Pred-Clysma Precortisyl Predni-Helvacort Hydeltrasol Deltahydrocortisone (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione Delta- Cortef Aprednislon .delta.1-Hydrocortisone Delta(1)Hydrocortisone Predeltilone PREDNISOLONE Dontisolon D Adnisolone Capsoid Cortalone Dacortin H Decortin H Delta-F Dhasolone Estilsona Fisopred Frisolona Gupisone Hydeltra Klismacort Lenisolone Linola-H N Meti Derm Opredsone Prelone Prenilone Sterane |
|
| Definitions |
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C769 |
|
| Accepted_Therapeutic_Use_For |
Inflammatory conditions; Allergic conditions; Hematologic conditions; Neoplastic conditions; Autoimmune conditions; Replacement therapy in adrenal insufficiency |
|
| ALT_DEFINITION |
A drug that lessens inflammation and suppresses the body's immune response. It may also kill cancer cells. Prednisolone is used to treat disorders in many organ systems and to treat the symptoms of several types of leukemia and lymphoma. It is also being studied in the treatment of other types of cancer. Prednisolone is a type of therapeutic glucocorticoid. |
|
| CAS_Registry |
50-24-8 |
|
| CHEBI_ID |
CHEBI:8378 |
|
| Chemical_Formula |
C21H28O5 |
|
| code |
C769 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04) |
|
| Display_Name |
Prednisolone |
|
| FDA_UNII_Code |
9PHQ9Y1OLM |
|
| FULL_SYN |
Lepi-Cortinolo Meticortelone 1,2-Dehydrohydrocortisone Delta-Cortef Di-Adreson-F Delta-Diona Kuhlprednon Delta1-dehydro-hydrocortisone Deltacortril Hostacortin H Predni-Coelin Cortisolone Deltidrosol Longiprednil prednisolone Delta-Phoricol Prednisolone Linola-H-Fett N Prednisolonum Deltasolone Prednicortelone Panafcortelone Metacortandralone Decaprednil Pred-Clysma Precortisyl Predni-Helvacort Hydeltrasol Deltahydrocortisone (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione Delta- Cortef Aprednislon .delta.1-Hydrocortisone Delta(1)Hydrocortisone Predeltilone PREDNISOLONE Dontisolon D Adnisolone Capsoid Cortalone Dacortin H Decortin H Delta-F Dhasolone Estilsona Fisopred Frisolona Gupisone Hydeltra Klismacort Lenisolone Linola-H N Meti Derm Opredsone Prelone Prenilone Sterane |
|
| Has_Salt_Form |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1403 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80823 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1202 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1402 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1862 |
|
| Is_Value_For_GDC_Property | ||
| label |
Prednisolone |
|
| Legacy Concept Name |
Prednisolone |
|
| Maps_To |
Prednisolone |
|
| NCI_Drug_Dictionary_ID |
43296 |
|
| NSC Number |
9120 |
|
| PDQ_Closed_Trial_Search_ID |
43296 |
|
| PDQ_Open_Trial_Search_ID |
43296 |
|
| Preferred_Name |
Prednisolone |
|
| prefixIRI |
Thesaurus:C769 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0032950 |
|
| subClassOf |