National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Tacrolimus Anhydrous
Synonyms

Tacrolimus Anhydrous

Tsukubaenolide

TACROLIMUS ANHYDROUS

(-)-FK 506

Advagraf

Avagraf
Definitions

Anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76066
CAS_Registry

104987-11-3
CHEBI_ID

CHEBI:61049
Chemical_Formula

C44H69NO12
code

C76066
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

Anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.
FDA_UNII_Code

Y5L2157C4J
FULL_SYN

Tacrolimus Anhydrous

Tsukubaenolide

TACROLIMUS ANHYDROUS

(-)-FK 506

Advagraf

Avagraf
label

Tacrolimus Anhydrous
Legacy Concept Name

Anhydrous_Tacrolimus
Preferred_Name

Tacrolimus Anhydrous
prefixIRI

Thesaurus:C76066
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0771204
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C146638
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