loading...| Preferred Name |
Tacrolimus Anhydrous |
|
| Synonyms |
Tacrolimus Anhydrous Tsukubaenolide TACROLIMUS ANHYDROUS (-)-FK 506 Advagraf Avagraf |
|
| Definitions |
Anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76066 |
|
| CAS_Registry |
104987-11-3 |
|
| CHEBI_ID |
CHEBI:61049 |
|
| Chemical_Formula |
C44H69NO12 |
|
| code |
C76066 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
Anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. |
|
| FDA_UNII_Code |
Y5L2157C4J |
|
| FULL_SYN |
Tacrolimus Anhydrous Tsukubaenolide TACROLIMUS ANHYDROUS (-)-FK 506 Advagraf Avagraf |
|
| label |
Tacrolimus Anhydrous |
|
| Legacy Concept Name |
Anhydrous_Tacrolimus |
|
| Preferred_Name |
Tacrolimus Anhydrous |
|
| prefixIRI |
Thesaurus:C76066 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0771204 |
|
| subClassOf |