loading...| Preferred Name | Retinoblastoma | |
| Synonyms |
Retinoblastoma RETINOBLASTOMA, MALIGNANT retinoblastoma Retinoblastoma, NOS RB |
|
| Definitions |
A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7541 |
|
| ALT_DEFINITION |
A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. Cancer that forms in the tissues of the retina (the light-sensitive layers of nerve tissue at the back of the eye). Retinoblastoma usually occurs in children younger than 5 years. It may be hereditary or nonhereditary (sporadic). A malignant neoplasm originating in the nuclear layer of the retina. |
|
| code |
C7541 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C138190 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156952 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168661 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168656 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168662 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77526 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88025 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103061 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156966 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168658 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192842 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126659 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118168 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C165258 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102905 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189762 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132009 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168655 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C138188 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158520 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179491 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168657 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118464 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 |
|
| Contributing_Source |
Cellosaurus CDISC CPTAC CTEP CTRP GDC MedDRA NICHD PCDC |
|
| DEFINITION |
A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. |
|
| Display_Name |
Retinoblastoma |
|
| FULL_SYN |
Retinoblastoma RETINOBLASTOMA, MALIGNANT retinoblastoma Retinoblastoma, NOS RB |
|
| ICD-O-3_Code |
9510/3 |
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| Is_Value_For_GDC_Property | ||
| label |
Retinoblastoma |
|
| Legacy Concept Name |
Retinoblastoma |
|
| Maps_To |
Retinoblastoma Retinoblastoma, NOS 9510/3 |
|
| Neoplasm_Has_Special_Category | ||
| Neoplastic_Status |
Malignant |
|
| Preferred_Name |
Retinoblastoma |
|
| prefixIRI |
Thesaurus:C7541 |
|
| Semantic_Type |
Neoplastic Process |
|
| UMLS_CUI |
C0035335 |
|
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3216 |