loading...| Preferred Name | Omeprazole Sodium | |
| Synonyms |
Omeprazole Sodium OMEPRAZOLE SODIUM Omeprazole |
|
| Definitions |
The sodium salt form of a benzimidazole with selective and irreversible proton pump inhibitor activity. In the acidic compartment of parietal cells, omeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74598 |
|
| CAS_Registry |
95510-70-6 |
|
| Chemical_Formula |
C17H18N3O3S.Na |
|
| code |
C74598 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156952 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159412 |
|
| Contributing_Source |
CPTAC FDA |
|
| DEFINITION |
The sodium salt form of a benzimidazole with selective and irreversible proton pump inhibitor activity. In the acidic compartment of parietal cells, omeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell. |
|
| FDA_UNII_Code |
KV03YZ6QLW |
|
| FULL_SYN |
Omeprazole Sodium OMEPRAZOLE SODIUM Omeprazole |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Omeprazole Sodium |
|
| Legacy Concept Name |
Omeprazole_Sodium |
|
| Preferred_Name |
Omeprazole Sodium |
|
| prefixIRI |
Thesaurus:C74598 |
|
| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0771315 |
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| subClassOf |