loading...| Preferred Name |
Proton Pump Inhibitor |
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| Synonyms |
Proton Pump Inhibitors Proton Pump Inhibitor PPI |
|
| Definitions |
Any one of the substituted benzimidazole compounds with anti-ulcer activity. A proton pump inhibitor is orally administered in the neutrally charged, inactive form and, upon entering the acidic environment of the parietal cell, gets protonated and converted into its active form. The active form will covalently and irreversibly bind to the proton pump, the H+/K+-ATPase, located on the surface of parietal cells. This leads to an inhibition of the transport of hydrogen ions, in exchange for potassium ions, into the gastric lumen and results in an inhibition of gastric acid secretion. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29723 |
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| ALT_DEFINITION |
A pharmaceutical agent that inhibits the transport of hydrogen ions, in exchange for potassium ions, into the gastric lumen and results in an inhibition of gastric acid secretion. These drugs are used for their anti-ulcer activity. |
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| CHEBI_ID |
CHEBI:49200 |
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| code |
C29723 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118468 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP GDC NICHD |
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| DEFINITION |
Any one of the substituted benzimidazole compounds with anti-ulcer activity. A proton pump inhibitor is orally administered in the neutrally charged, inactive form and, upon entering the acidic environment of the parietal cell, gets protonated and converted into its active form. The active form will covalently and irreversibly bind to the proton pump, the H+/K+-ATPase, located on the surface of parietal cells. This leads to an inhibition of the transport of hydrogen ions, in exchange for potassium ions, into the gastric lumen and results in an inhibition of gastric acid secretion. |
|
| Display_Name |
Proton Pump Inhibitor |
|
| FULL_SYN |
Proton Pump Inhibitors Proton Pump Inhibitor PPI |
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| Is_Value_For_GDC_Property | ||
| label |
Proton Pump Inhibitor |
|
| Legacy Concept Name |
Proton_Pump_Inhibitor |
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| Maps_To |
Proton Pump Inhibitors |
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| Preferred_Name |
Proton Pump Inhibitor |
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| prefixIRI |
Thesaurus:C29723 |
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| Semantic_Type |
Chemical Viewed Functionally |
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| UMLS_CUI |
C0358591 |
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| subClassOf |