loading...| Preferred Name | Phenobarbital | |
| Synonyms |
Phenobarbital phenobarbital 5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione PHENOBARBITAL PHENO |
|
| Definitions |
A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C739 |
|
| Accepted_Therapeutic_Use_For |
Epilepsy |
|
| ALT_DEFINITION |
A drug that is used to treat seizures and as a sedative. It is being studied in the treatment of diarrhea and for its ability to increase the antitumor effect of other therapies. It belongs to the family of drugs called barbiturates. |
|
| CAS_Registry |
50-06-6 |
|
| CHEBI_ID |
CHEBI:8069 |
|
| Chemical_Formula |
C12H12N2O3 |
|
| code |
C739 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization. |
|
| FDA_UNII_Code |
YQE403BP4D |
|
| FULL_SYN |
Phenobarbital phenobarbital 5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione PHENOBARBITAL PHENO |
|
| Has_Salt_Form | ||
| label |
Phenobarbital |
|
| Legacy Concept Name |
Phenobarbital |
|
| NCI_Drug_Dictionary_ID |
42405 |
|
| NSC Number |
128143 9848 |
|
| PDQ_Closed_Trial_Search_ID |
42405 |
|
| PDQ_Open_Trial_Search_ID |
42405 |
|
| Preferred_Name |
Phenobarbital |
|
| prefixIRI |
Thesaurus:C739 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0031412 |
|
| subClassOf |