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National Cancer Institute Thesaurus
| Preferred Name | Ambrisentan | |
| Synonyms |
(+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic Acid AMBRISENTAN Ambrisentan BSF-208075 LU-208075 Letairis Pulmonext Volibris |
|
| Definitions |
An orally bioavailable, selective antagonist of the endothelin type-A (ETA) receptor that may be used for the treatment of pulmonary arterial hypertension (PAH). Upon administration, ambrisentan targets and binds to ETA receptor, which prevents the binding of endothelin-1 (ET-1) to the ETA receptor and ET-1/ETA-mediated vasoconstriction and cell proliferation. This may lead to vasodilation. ET-1 concentrations are increased in plasma as well as lung tissue in PAH, and ET-1 may play a key role in the pathogenesis of PAH. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72694 |
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| CAS_Registry |
177036-94-1
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|
| Chemical_Formula |
C22H22N2O4
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|
| code |
C72694
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 |
|
| Contributing_Source |
FDA
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|
| DEFINITION |
An orally bioavailable, selective antagonist of the endothelin type-A (ETA) receptor that may be used for the treatment of pulmonary arterial hypertension (PAH). Upon administration, ambrisentan targets and binds to ETA receptor, which prevents the binding of endothelin-1 (ET-1) to the ETA receptor and ET-1/ETA-mediated vasoconstriction and cell proliferation. This may lead to vasodilation. ET-1 concentrations are increased in plasma as well as lung tissue in PAH, and ET-1 may play a key role in the pathogenesis of PAH.
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|
| FDA_UNII_Code |
HW6NV07QEC
|
|
| FULL_SYN |
(+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic Acid AMBRISENTAN Ambrisentan BSF-208075 LU-208075 Letairis Pulmonext Volibris
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|
| label |
Ambrisentan
|
|
| Legacy Concept Name |
Ambrisentan
|
|
| Preferred_Name |
Ambrisentan
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|
| prefixIRI |
Thesaurus:C72694
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C1176329
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| subClassOf |
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