loading...| Preferred Name |
Pioglitazone |
|
| Synonyms |
pioglitazone Pioglitazone PIOGLITAZONE |
|
| Definitions |
An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71633 |
|
| ALT_DEFINITION |
A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth) from developing into cancer. It is a type of thiazolidinedione. |
|
| CAS_Registry |
111025-46-8 |
|
| CHEBI_ID |
CHEBI:8228 |
|
| Chemical_Formula |
C19H20N2O3S |
|
| code |
C71633 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. |
|
| Display_Name |
Pioglitazone |
|
| FDA_UNII_Code |
X4OV71U42S |
|
| FULL_SYN |
pioglitazone Pioglitazone PIOGLITAZONE |
|
| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Pioglitazone |
|
| Legacy Concept Name |
Pioglitazone_Base |
|
| Maps_To |
Pioglitazone |
|
| Preferred_Name |
Pioglitazone |
|
| prefixIRI |
Thesaurus:C71633 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0071097 |
|
| subClassOf |