National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Thiazolidinedione Antidiabetic Agent
Synonyms

Thiazolidinedione Antidiabetic Agent

Thiazolidinedione
Definitions

Any antidiabetic agent with the glitazone (thiazolidinedione) base structure with antihyperglycemic activity. Glitazone antidiabetic agents selectively bind to and stimulate the nuclear receptor peroxisome proliferator-activated receptor (PPAR) gamma. This results in the selective transcription of a number of insulin-sensitive genes involved in glucose metabolism. This eventually enhances insulin sensitivity, reduces insulin resistance and decreases hepatic gluconeogenesis. PPARs function as transcription factors that regulate expressions of genes involved in cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), as well as tumorigenesis; PPARgamma is expressed at high levels in adipose tissue.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98241
code

C98241
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537
Contributing_Source

GDC
DEFINITION

Any antidiabetic agent with the glitazone (thiazolidinedione) base structure with antihyperglycemic activity. Glitazone antidiabetic agents selectively bind to and stimulate the nuclear receptor peroxisome proliferator-activated receptor (PPAR) gamma. This results in the selective transcription of a number of insulin-sensitive genes involved in glucose metabolism. This eventually enhances insulin sensitivity, reduces insulin resistance and decreases hepatic gluconeogenesis. PPARs function as transcription factors that regulate expressions of genes involved in cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), as well as tumorigenesis; PPARgamma is expressed at high levels in adipose tissue.
FULL_SYN

Thiazolidinedione Antidiabetic Agent

Thiazolidinedione
Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99532
label

Thiazolidinedione Antidiabetic Agent
Maps_To

Thiazolidinedione
Preferred_Name

Thiazolidinedione Antidiabetic Agent
prefixIRI

Thesaurus:C98241
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C3273907
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29711
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http://purl.obolibrary.org/obo/NCIT_C98241 BERO LOOM