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National Cancer Institute Thesaurus
| Preferred Name | Nortriptyline Hydrochloride | |
| Synonyms |
NORTRIPTYLINE HYDROCHLORIDE Nortriptyline Hydrochloride 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-, Hydrochloride Allegron Norpress Pamelor |
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| Definitions |
The hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C704 |
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| Accepted_Therapeutic_Use_For |
Depression
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| CAS_Registry |
894-71-3
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|
| Chemical_Formula |
C19H21N.HCl
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|
| code |
C704
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
The hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.
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| FDA_UNII_Code |
00FN6IH15D
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|
| FULL_SYN |
NORTRIPTYLINE HYDROCHLORIDE Nortriptyline Hydrochloride 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-, Hydrochloride Allegron Norpress Pamelor
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|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Nortriptyline Hydrochloride
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|
| Legacy Concept Name |
Nortriptyline
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| NCI_Drug_Dictionary_ID |
41535
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|
| NSC Number |
169453
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|
| PDQ_Closed_Trial_Search_ID |
41535
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|
| PDQ_Open_Trial_Search_ID |
41535
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| Preferred_Name |
Nortriptyline Hydrochloride
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| prefixIRI |
Thesaurus:C704
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0700459
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| subClassOf |
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