loading...| Preferred Name |
Masoprocol |
|
| Synonyms |
Nordihydroguaiaretic Acid Nordihydroguaiaretic acid 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol] Actinex MASOPROCOL Masoprocol NDGA NDHGA masoprocol |
|
| Definitions |
A naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. Masoprocol directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, masoprocol inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrienes. It may prevent leukocyte infiltration into tissues and the release of reactive oxygen species. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C701 |
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| ALT_DEFINITION |
A drug put on the skin to treat growths caused by sun exposure. A form of Masoprocol that is taken by mouth is being studied in the treatment of prostate cancer. Masoprocol is an antioxidant, and it may block certain enzymes needed for tumor growth. |
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| CAS_Registry |
27686-84-6 |
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| Chemical_Formula |
C18H22O4 |
|
| code |
C701 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
A naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. Masoprocol directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, masoprocol inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrienes. It may prevent leukocyte infiltration into tissues and the release of reactive oxygen species. |
|
| Display_Name |
Masoprocol |
|
| FDA_UNII_Code |
7BO8G1BYQU |
|
| FULL_SYN |
Nordihydroguaiaretic Acid Nordihydroguaiaretic acid 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol] Actinex MASOPROCOL Masoprocol NDGA NDHGA masoprocol |
|
| Has_Target |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17531 |
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| Is_Value_For_GDC_Property | ||
| label |
Masoprocol |
|
| Legacy Concept Name |
Nordihydroguaiaretic_Acid |
|
| Maps_To |
Masoprocol |
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| NCI_Drug_Dictionary_ID |
479648 |
|
| NSC Number |
4291 |
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| PDQ_Closed_Trial_Search_ID |
479648 |
|
| PDQ_Open_Trial_Search_ID |
479648 |
|
| Preferred_Name |
Masoprocol |
|
| prefixIRI |
Thesaurus:C701 |
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| PubMedID_Primary_Reference |
8450672 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0733397 |
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| subClassOf |