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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Dronedarone | |
| Synonyms |
DRONEDARONE Dronedarone |
|
| Definitions |
An orally bioavailable benzofuran derivative, with anti-arrhythmic activity. Upon oral administration, and although the exact mechanism of action through which dronedarone exerts its anti-arrhythmic effect has not been fully elucidated, it inhibits multiple voltage-gated ion channels, including sodium, potassium, and calcium ion channels, and restores the normal sinus rhythm and reduces heart rate in atrial fibrillation. It also non-competitively antagonizes adrenergic receptors. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65485 |
|
| CAS_Registry |
141626-36-0
|
|
| CHEBI_ID |
CHEBI:50659
|
|
| Chemical_Formula |
C31H44N2O5S
|
|
| code |
C65485
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
An orally bioavailable benzofuran derivative, with anti-arrhythmic activity. Upon oral administration, and although the exact mechanism of action through which dronedarone exerts its anti-arrhythmic effect has not been fully elucidated, it inhibits multiple voltage-gated ion channels, including sodium, potassium, and calcium ion channels, and restores the normal sinus rhythm and reduces heart rate in atrial fibrillation. It also non-competitively antagonizes adrenergic receptors.
|
|
| FDA_UNII_Code |
JQZ1L091Y2
|
|
| FULL_SYN |
DRONEDARONE Dronedarone
|
|
| Has_Salt_Form | ||
| label |
Dronedarone
|
|
| Legacy Concept Name |
Dronedarone
|
|
| Preferred_Name |
Dronedarone
|
|
| prefixIRI |
Thesaurus:C65485
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0766326
|
|
| subClassOf |
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