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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Metronidazole | |
| Synonyms |
Flagyl I.V. RTU METRONIDAZOLE metronidazole Metronidazole Flagyl Tricom |
|
| Definitions |
A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C651 |
|
| ALT_DEFINITION |
A drug that is used to treat infection and is being studied in the treatment of cancer. It is a type of antibacterial, antiprotozoal, and anthelmintic.
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|
| CAS_Registry |
443-48-1
|
|
| CHEBI_ID |
CHEBI:6909
|
|
| Chemical_Formula |
C6H9N3O3
|
|
| code |
C651
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA HemOnc
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|
| DEFINITION |
A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth.
|
|
| FDA_UNII_Code |
140QMO216E
|
|
| FULL_SYN |
Flagyl I.V. RTU METRONIDAZOLE metronidazole Metronidazole Flagyl Tricom
|
|
| Has_Salt_Form | ||
| label |
Metronidazole
|
|
| Legacy Concept Name |
Metronidazole
|
|
| NSC Number |
50364 69587
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|
| Preferred_Name |
Metronidazole
|
|
| prefixIRI |
Thesaurus:C651
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0025872
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|
| subClassOf |
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