loading...| Preferred Name | Pregabalin | |
| Synonyms |
3-(Aminomethyl)-5-methyl-hexanoic Acid 3-Isobutyl GABA CI 1008 Lyrica PD 144723 PREGABALIN Pregabalin pregabalin |
|
| Definitions |
A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64625 |
|
| ALT_DEFINITION |
A drug used to treat nerve pain caused by diabetes or herpes zoster infection and certain types of seizures. It is being studied in the prevention and treatment of nerve pain in the hands and feet of cancer patients given chemotherapy. Pregabalin is a type of anticonvulsant. |
|
| CAS_Registry |
148553-50-8 |
|
| CHEBI_ID |
CHEBI:64356 |
|
| Chemical_Formula |
C8H17NO2 |
|
| code |
C64625 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation. |
|
| Display_Name |
Pregabalin |
|
| FDA_UNII_Code |
55JG375S6M |
|
| FULL_SYN |
3-(Aminomethyl)-5-methyl-hexanoic Acid 3-Isobutyl GABA CI 1008 Lyrica PD 144723 PREGABALIN Pregabalin pregabalin |
|
| label |
Pregabalin |
|
| Legacy Concept Name |
Pregabalin |
|
| NCI_Drug_Dictionary_ID |
518288 |
|
| NSC Number |
759256 |
|
| PDQ_Closed_Trial_Search_ID |
518288 |
|
| PDQ_Open_Trial_Search_ID |
518288 |
|
| Preferred_Name |
Pregabalin |
|
| prefixIRI |
Thesaurus:C64625 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0657912 |
|
| subClassOf |