National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Trientine Hydrochloride

Synonyms

Trientine Hydrochloride

N,N-bis (2-aminoethyl)-1,2-ethanediamine Dihydrochloride

TRIENTINE HYDROCHLORIDE

Syprine

Definitions

The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8).

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61987

CAS_Registry

38260-01-4

Chemical_Formula

C6H18N4.2HCl

code

C61987

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

DEFINITION

The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8).

Display_Name

Trientine Hydrochloride

FDA_UNII_Code

HC3NX54582

FULL_SYN

Trientine Hydrochloride

N,N-bis (2-aminoethyl)-1,2-ethanediamine Dihydrochloride

TRIENTINE HYDROCHLORIDE

Syprine

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66633

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Trientine Hydrochloride

Legacy Concept Name

Trientine_Hydrochloride

Maps_To

Trientine Hydrochloride

NCI_Drug_Dictionary_ID

683662

PDQ_Closed_Trial_Search_ID

683662

PDQ_Open_Trial_Search_ID

683662

Preferred_Name

Trientine Hydrochloride

prefixIRI

Thesaurus:C61987

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0770325

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1742

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C360

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