loading...| Preferred Name |
Trientine Hydrochloride |
|
| Synonyms |
Trientine Hydrochloride N,N-bis (2-aminoethyl)-1,2-ethanediamine Dihydrochloride TRIENTINE HYDROCHLORIDE Syprine |
|
| Definitions |
The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8). |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61987 |
|
| CAS_Registry |
38260-01-4 |
|
| Chemical_Formula |
C6H18N4.2HCl |
|
| code |
C61987 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8). |
|
| Display_Name |
Trientine Hydrochloride |
|
| FDA_UNII_Code |
HC3NX54582 |
|
| FULL_SYN |
Trientine Hydrochloride N,N-bis (2-aminoethyl)-1,2-ethanediamine Dihydrochloride TRIENTINE HYDROCHLORIDE Syprine |
|
| Has_Free_Acid_Or_Base_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Trientine Hydrochloride |
|
| Legacy Concept Name |
Trientine_Hydrochloride |
|
| Maps_To |
Trientine Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
683662 |
|
| PDQ_Closed_Trial_Search_ID |
683662 |
|
| PDQ_Open_Trial_Search_ID |
683662 |
|
| Preferred_Name |
Trientine Hydrochloride |
|
| prefixIRI |
Thesaurus:C61987 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0770325 |
|
| subClassOf |