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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Rosuvastatin Calcium | |
| Synonyms |
ROSUVASTATIN CALCIUM Rosuvastatin Calcium rosuvastatin calcium Crestor |
|
| Definitions |
The calcium salt form of rosuvastatin, a statin with antilipidemic activity. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61933 |
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| Accepted_Therapeutic_Use_For |
Atherosclerosis
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| ALT_DEFINITION |
A drug used to lower the amount of cholesterol and other harmful substances, such as triglycerides, in the blood. It is also being studied in the prevention and treatment of some types of cancer and other conditions. Crestor blocks an enzyme that helps make cholesterol in the body and it helps break down cholesterol. It also may cause cancer cells to die and may inhibit the growth of blood vessels that cancer cells need to grow. It is a type of HMG-CoA reductase inhibitor and a type of statin.
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| CAS_Registry |
147098-20-2
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|
| Chemical_Formula |
2C22H27FN3O6S.Ca
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|
| code |
C61933
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
The calcium salt form of rosuvastatin, a statin with antilipidemic activity. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol.
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|
| Display_Name |
Rosuvastatin Calcium
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|
| FDA_UNII_Code |
83MVU38M7Q
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|
| FULL_SYN |
ROSUVASTATIN CALCIUM Rosuvastatin Calcium rosuvastatin calcium Crestor
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|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| label |
Rosuvastatin Calcium
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|
| Legacy Concept Name |
Rosuvastatin_Calcium
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|
| NCI_Drug_Dictionary_ID |
654583
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|
| PDQ_Closed_Trial_Search_ID |
654583
|
|
| PDQ_Open_Trial_Search_ID |
654583
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|
| Preferred_Name |
Rosuvastatin Calcium
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|
| prefixIRI |
Thesaurus:C61933
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C1101751
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| subClassOf |
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