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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Ketamine | |
| Synonyms |
KETAMINE Ketamine ketamine |
|
| Definitions |
A cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including inhibition of biogenic amine uptake, binding to opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Because of the involvement of spinal NMDA receptors in the process of central sensitization, this agent may reduce pain perception and induce sedation. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61797 |
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| ALT_DEFINITION |
A drug used to cause a loss of feeling and awareness and to induce sleep in patients having surgery. It is also being studied in the treatment of nerve pain caused by chemotherapy. Ketamine blocks pathways to the brain that are involved in sensing pain. It is a type of general anesthetic.
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| CAS_Registry |
6740-88-1
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| CHEBI_ID |
CHEBI:6121
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| Chemical_Formula |
C13H16ClNO
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|
| code |
C61797
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
A cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including inhibition of biogenic amine uptake, binding to opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Because of the involvement of spinal NMDA receptors in the process of central sensitization, this agent may reduce pain perception and induce sedation.
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| Display_Name |
Ketamine
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| FDA_UNII_Code |
690G0D6V8H
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| FULL_SYN |
KETAMINE Ketamine ketamine
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| Has_Salt_Form | ||
| label |
Ketamine
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|
| Legacy Concept Name |
Ketamine
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| Preferred_Name |
Ketamine
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|
| prefixIRI |
Thesaurus:C61797
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0022614
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| subClassOf |
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