loading...| Preferred Name | Docetaxel Anhydrous | |
| Synonyms |
Docetaxel Anhydrous DOCETAXEL ANHYDROUS DOCEFREZ |
|
| Definitions |
The anhydrous form of docetaxel, a semisynthetic side-chain analogue of paclitaxel with antineoplastic property. Docetaxel binds specifically to the beta-tubulin subunit of microtubules and thereby antagonizes the disassembly of the microtubule proteins. This results in the persistence of aberrant microtubule structures and results in cell-cycle arrest and subsequent cell death. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61734 |
|
| CAS_Registry |
114977-28-5 |
|
| CHEBI_ID |
CHEBI:4672 |
|
| Chemical_Formula |
C43H53NO14 |
|
| code |
C61734 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
The anhydrous form of docetaxel, a semisynthetic side-chain analogue of paclitaxel with antineoplastic property. Docetaxel binds specifically to the beta-tubulin subunit of microtubules and thereby antagonizes the disassembly of the microtubule proteins. This results in the persistence of aberrant microtubule structures and results in cell-cycle arrest and subsequent cell death. |
|
| FDA_UNII_Code |
699121PHCA |
|
| FULL_SYN |
Docetaxel Anhydrous DOCETAXEL ANHYDROUS DOCEFREZ |
|
| Is_Value_For_GDC_Property | ||
| label |
Docetaxel Anhydrous |
|
| Legacy Concept Name |
Docetaxel_Anhydrous |
|
| Maps_To |
Docetaxel Anhydrous |
|
| NSC Number |
628503 |
|
| Preferred_Name |
Docetaxel Anhydrous |
|
| prefixIRI |
Thesaurus:C61734 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0771375 |
|
| subClassOf |