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National Cancer Institute Thesaurus
| Preferred Name | Citrulline | |
| Synonyms |
N5-(Aminocarbonyl)-L-ornithine 2-Amino-5-(carbamoylamino)pentanoic Acid L-Citrulline CITRULLINE Citrulline |
|
| Definitions |
A non-essential amino acid. In hepatocytes, L-citrulline is synthesized in the urea cycle by the addition of carbon dioxide and ammonia to ornithine. L-citrulline is converted into L-arginine by the enzymes argininosuccinate synthetase and argininosuccinate lyase in the presence of L-aspartate and ATP. Subsequently, L-arginine is converted to nitric oxide by nitric oxide synthase and L-citrulline is regenerated as a by-product. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C53406 |
|
| CAS_Registry |
372-75-8
|
|
| CHEBI_ID |
CHEBI:16349
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|
| Chemical_Formula |
C6H13N3O3
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|
| code |
C53406
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
|
| Contributing_Source |
CTRP FDA
|
|
| DEFINITION |
A non-essential amino acid. In hepatocytes, L-citrulline is synthesized in the urea cycle by the addition of carbon dioxide and ammonia to ornithine. L-citrulline is converted into L-arginine by the enzymes argininosuccinate synthetase and argininosuccinate lyase in the presence of L-aspartate and ATP. Subsequently, L-arginine is converted to nitric oxide by nitric oxide synthase and L-citrulline is regenerated as a by-product.
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|
| Display_Name |
Citrulline
|
|
| FDA_UNII_Code |
29VT07BGDA
|
|
| FULL_SYN |
N5-(Aminocarbonyl)-L-ornithine 2-Amino-5-(carbamoylamino)pentanoic Acid L-Citrulline CITRULLINE Citrulline
|
|
| label |
Citrulline
|
|
| Legacy Concept Name |
Citrulline
|
|
| NCI_Drug_Dictionary_ID |
464795
|
|
| NSC Number |
27425
|
|
| PDQ_Closed_Trial_Search_ID |
464795
|
|
| PDQ_Open_Trial_Search_ID |
464795
|
|
| Preferred_Name |
Citrulline
|
|
| prefixIRI |
Thesaurus:C53406
|
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
|
|
| UMLS_CUI |
C0008864
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| subClassOf |
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