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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Pimozide | |
| Synonyms |
2H-Benzimidazol-2-one, 1-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidinyl)-1,3-dihydro- Opiran Orap PIMOZIDE Pimozide |
|
| Definitions |
A diphenylbutylpiperidine derivative and a dopamine antagonist with antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby decreasing dopamine neurotransmission and reducing the occurrence of motor and vocal tics and delusions of parasitosis. In addition, this agent antagonizes alpha-adrenergic and 5-HT2 receptors. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47672 |
|
| CAS_Registry |
2062-78-4
|
|
| CHEBI_ID |
CHEBI:8212
|
|
| Chemical_Formula |
C28H29F2N3O
|
|
| code |
C47672
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA
|
|
| DEFINITION |
A diphenylbutylpiperidine derivative and a dopamine antagonist with antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby decreasing dopamine neurotransmission and reducing the occurrence of motor and vocal tics and delusions of parasitosis. In addition, this agent antagonizes alpha-adrenergic and 5-HT2 receptors.
|
|
| Display_Name |
Pimozide
|
|
| FDA_UNII_Code |
1HIZ4DL86F
|
|
| FULL_SYN |
2H-Benzimidazol-2-one, 1-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidinyl)-1,3-dihydro- Opiran Orap PIMOZIDE Pimozide
|
|
| label |
Pimozide
|
|
| Legacy Concept Name |
Pimozide
|
|
| NSC Number |
170984
|
|
| Preferred_Name |
Pimozide
|
|
| prefixIRI |
Thesaurus:C47672
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0031935
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|
| subClassOf |
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