loading...| Preferred Name |
Maprotiline Hydrochloride |
|
| Synonyms |
MAPROTILINE HYDROCHLORIDE 1-(3-Methylaminopropyl)dibenzo(b,e)bicyclo(2.2.2)octadiene Hydrochloride Maprotiline Hydrochloride 9-(gamma-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene Hydrochloride Ludiomil |
|
| Definitions |
The hydrochloride salt form of maprotiline, a tetracyclic antidepressant closely related to the tricyclic antidepressants with adrenergic activity and sedative properties. Maprotiline hydrochloride exerts its effect by blocking the re-uptake of norepinephrine, thereby increasing the synaptic concentration of norepinephrine in the central nervous system and subsequently prolonging the action of norepinephrine on central receptors. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47594 |
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| CAS_Registry |
10347-81-6 |
|
| Chemical_Formula |
C20H23N.HCl |
|
| code |
C47594 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
The hydrochloride salt form of maprotiline, a tetracyclic antidepressant closely related to the tricyclic antidepressants with adrenergic activity and sedative properties. Maprotiline hydrochloride exerts its effect by blocking the re-uptake of norepinephrine, thereby increasing the synaptic concentration of norepinephrine in the central nervous system and subsequently prolonging the action of norepinephrine on central receptors. |
|
| FDA_UNII_Code |
7C8J54PVFI |
|
| FULL_SYN |
MAPROTILINE HYDROCHLORIDE 1-(3-Methylaminopropyl)dibenzo(b,e)bicyclo(2.2.2)octadiene Hydrochloride Maprotiline Hydrochloride 9-(gamma-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene Hydrochloride Ludiomil |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Maprotiline Hydrochloride |
|
| Legacy Concept Name |
Maprotiline_Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
802781 |
|
| PDQ_Closed_Trial_Search_ID |
802781 |
|
| PDQ_Open_Trial_Search_ID |
802781 |
|
| Preferred_Name |
Maprotiline Hydrochloride |
|
| prefixIRI |
Thesaurus:C47594 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0700455 |
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| subClassOf |