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National Cancer Institute Thesaurus
| Preferred Name | Ketoprofen | |
| Synonyms |
Propionic Acid, 2-(3-benzoylphenyl)- Benzeneacetic Acid, 3-benzoyl-alpha-methyl- Capisten KETOPROFEN Ketoprofen Orudis Oruvail |
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| Definitions |
A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of ibuprofen. Ketoprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47578 |
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| CAS_Registry |
22071-15-4
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| CHEBI_ID |
CHEBI:6128
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| Chemical_Formula |
C16H14O3
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| code |
C47578
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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| DEFINITION |
A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of ibuprofen. Ketoprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.
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| Display_Name |
Ketoprofen
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| FDA_UNII_Code |
90Y4QC304K
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| FULL_SYN |
Propionic Acid, 2-(3-benzoylphenyl)- Benzeneacetic Acid, 3-benzoyl-alpha-methyl- Capisten KETOPROFEN Ketoprofen Orudis Oruvail
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| Has_Target | ||
| label |
Ketoprofen
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|
| Legacy Concept Name |
Ketoprofen
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| NCI_Drug_Dictionary_ID |
743614
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| PDQ_Closed_Trial_Search_ID |
743614
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| PDQ_Open_Trial_Search_ID |
743614
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| Preferred_Name |
Ketoprofen
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| prefixIRI |
Thesaurus:C47578
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0022635
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| subClassOf |
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