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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Ethosuximide | |
| Synonyms |
Ethosuximide 3-Ethyl-3-methylpyrrolidine-2,5-dione ETHOSUXIMIDE Zarontin |
|
| Definitions |
A succinimide with anticonvulsant activity. The exact mechanism of action is not entirely understood, but most likely ethosuximide exerts its effects by partial antagonism of T-type calcium channels of the thalamic neurons. This leads to a decrease in burst firing of thalamocortical neurons, which stabilizes the nerve activity in the brain and prevents seizures. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47523 |
|
| CAS_Registry |
77-67-8
|
|
| CHEBI_ID |
CHEBI:4887
|
|
| Chemical_Formula |
C7H11NO2
|
|
| code |
C47523
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A succinimide with anticonvulsant activity. The exact mechanism of action is not entirely understood, but most likely ethosuximide exerts its effects by partial antagonism of T-type calcium channels of the thalamic neurons. This leads to a decrease in burst firing of thalamocortical neurons, which stabilizes the nerve activity in the brain and prevents seizures.
|
|
| FDA_UNII_Code |
5SEH9X1D1D
|
|
| FULL_SYN |
Ethosuximide 3-Ethyl-3-methylpyrrolidine-2,5-dione ETHOSUXIMIDE Zarontin
|
|
| label |
Ethosuximide
|
|
| Legacy Concept Name |
Ethosuximide
|
|
| NCI_Drug_Dictionary_ID |
694263
|
|
| NSC Number |
64013
|
|
| PDQ_Closed_Trial_Search_ID |
694263
|
|
| PDQ_Open_Trial_Search_ID |
694263
|
|
| Preferred_Name |
Ethosuximide
|
|
| prefixIRI |
Thesaurus:C47523
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0015043
|
|
| subClassOf |
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