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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Amoxapine | |
| Synonyms |
Dibenz(b,f)(1,4)oxazepine, 2-Chloro-11-(1-piperazinyl)- AMOXAPINE Amoxapine Asendin Demolox |
|
| Definitions |
A tricyclic antidepressant of the dibenzoxazepine class. Amoxapine exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47397 |
|
| CAS_Registry |
14028-44-5
|
|
| CHEBI_ID |
CHEBI:2675
|
|
| Chemical_Formula |
C17H16ClN3O
|
|
| code |
C47397
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A tricyclic antidepressant of the dibenzoxazepine class. Amoxapine exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent.
|
|
| FDA_UNII_Code |
R63VQ857OT
|
|
| FULL_SYN |
Dibenz(b,f)(1,4)oxazepine, 2-Chloro-11-(1-piperazinyl)- AMOXAPINE Amoxapine Asendin Demolox
|
|
| label |
Amoxapine
|
|
| Legacy Concept Name |
Amoxapine
|
|
| Preferred_Name |
Amoxapine
|
|
| prefixIRI |
Thesaurus:C47397
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0700992
|
|
| subClassOf |
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