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National Cancer Institute Thesaurus
| Preferred Name | Mantle Cell Lymphoma | |
| Synonyms |
mantle cell lymphoma Mantle cell lymphoma Mantle Cell Lymphoma Classical Mantle Cell Lymphoma Mantle zone lymphoma Mantle cell lymphoma, unspecified site Mantle Zone Lymphoma MCL |
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| Definitions |
A non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4337 |
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| ALT_DEFINITION |
An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that usually occurs in middle-aged or older adults. It is marked by small- to medium-size cancer cells that may be in the lymph nodes, spleen, bone marrow, blood, and gastrointestinal system.
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| code |
C4337
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156952 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168661 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168656 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168662 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193175 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156966 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168658 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193248 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192842 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126659 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118168 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C165258 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103133 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102905 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193231 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193006 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168655 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158520 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193249 |
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| Contributing_Source |
Cellosaurus CPTAC CTEP CTRP GDC mCode
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|
| DEFINITION |
A non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA.
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|
| Display_Name |
Mantle Cell Lymphoma
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| FULL_SYN |
mantle cell lymphoma Mantle cell lymphoma Mantle Cell Lymphoma Classical Mantle Cell Lymphoma Mantle zone lymphoma Mantle cell lymphoma, unspecified site Mantle Zone Lymphoma MCL
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| ICD-O-3_Code |
9673/3
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| Is_Value_For_GDC_Property | ||
| label |
Mantle Cell Lymphoma
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| Legacy Concept Name |
Mantle_Cell_Lymphoma
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| Maps_To |
Mantle cell lymphoma, lymph nodes of multiple sites Mantle cell lymphoma Mantle cell lymphoma (Includes all variants blastic, pleomorphic, small cell) Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Mantle cell lymphoma, extranodal and solid organ sites Mantle cell lymphoma, unspecified site, extranodal and solid organ sites Mantle zone lymphoma Mantle cell lymphoma, unspecified site 9673/3
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| Neoplastic_Status |
Malignant
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| Preferred_Name |
Mantle Cell Lymphoma
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| prefixIRI |
Thesaurus:C4337
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| Semantic_Type |
Neoplastic Process
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| UMLS_CUI |
C0334634
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| subClassOf |
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