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National Cancer Institute Thesaurus
| Preferred Name | Cytarabine | |
| Synonyms |
1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone .beta.-Cytosine arabinoside Tarabine PFS Aracytidine Beta-Cytosine Arabinoside 2(1H)-Pyrimidinone, 4-Amino-1-beta-D-arabinofuranosyl- 2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl- Cytosine Arabinoside Beta-cytosine Arabinoside Cytosine-.beta.-arabinoside 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone Cytarabinum Arabinofuranosylcytosine 1-Beta-D-arabinofuranosylcytosine Cytosine-beta-arabinoside 1-.beta.-D-Arabinofuranosylcytosine Arabinosylcytosine 1.beta.-D-Arabinofuranosylcytosine 1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone ARA-cell Alexan Ara-C Arabine Aracytin Aracytine CHX-3311 CYTARABINE Cytarabine Cytarbel Cytosar Cytosar-U Erpalfa Starasid U 19920 U-19920 Udicil WR-28453 cytarabine |
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| Definitions |
An antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C408 |
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| Accepted_Therapeutic_Use_For |
Acute lymphocytic leukemia; Acute Nonlymphocytic leukemia; Bone marrow transplantation; Carcinomatous meningitis; Chronic myelogenous leukemia; Hogkins disease; Meningeal leukemia; Acute Myeloid Leukemia; Meningitis lymphomatous; Myelodysplasic syndrome; Non-Hodgkins lymphoma; Ovarian cancer, intraperitoneal treatment; Retinoblastoma
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| ALT_DEFINITION |
A drug used to treat certain types of leukemia and prevent the spread of leukemia to the meninges (three thin layers of tissue that cover and protect the brain and spinal cord). It is also being studied in the treatment of other types of cancer. Cytarabine blocks tumor growth by stopping DNA synthesis. It is a type of antimetabolite.
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| CAS_Registry |
147-94-4
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| CHEBI_ID |
CHEBI:28680
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| Chemical_Formula |
C9H13N3O5
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| code |
C408
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
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| Contributing_Source |
CTRP FDA GDC HemOnc PCDC
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| DEFINITION |
An antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. (NCI04)
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| Display_Name |
Cytarabine
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| FDA_UNII_Code |
04079A1RDZ
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| FULL_SYN |
1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone .beta.-Cytosine arabinoside Tarabine PFS Aracytidine Beta-Cytosine Arabinoside 2(1H)-Pyrimidinone, 4-Amino-1-beta-D-arabinofuranosyl- 2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl- Cytosine Arabinoside Beta-cytosine Arabinoside Cytosine-.beta.-arabinoside 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone Cytarabinum Arabinofuranosylcytosine 1-Beta-D-arabinofuranosylcytosine Cytosine-beta-arabinoside 1-.beta.-D-Arabinofuranosylcytosine Arabinosylcytosine 1.beta.-D-Arabinofuranosylcytosine 1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone ARA-cell Alexan Ara-C Arabine Aracytin Aracytine CHX-3311 CYTARABINE Cytarabine Cytarbel Cytosar Cytosar-U Erpalfa Starasid U 19920 U-19920 Udicil WR-28453 cytarabine
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| Has_Salt_Form | ||
| Has_Target | ||
| Is_PCDC_AML_Authorized_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Cytarabine
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| Legacy Concept Name |
Cytosine_Arabinoside
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| Maps_To |
Cytarabine
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| NCI_Drug_Dictionary_ID |
39015
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| NSC Number |
287459
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| PDQ_Closed_Trial_Search_ID |
39015
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| PDQ_Open_Trial_Search_ID |
39015
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| Preferred_Name |
Cytarabine
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| prefixIRI |
Thesaurus:C408
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| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI |
C0010711
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| subClassOf |
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