loading...| Preferred Name | Cimetidine | |
| Synonyms |
N-Cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine Guanidine, N''-Cyano-N-Methyl-N'-(2-(((5-Methyl-1H-Imidazol-4-yl)Methyl)Thio)Ethyl)- CIMETIDINE Cimetidine Tagamet cimetidine |
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| Definitions |
A histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine's ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C374 |
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| Accepted_Therapeutic_Use_For |
Gastrointestinal conditions; allergic reaction prevention; immune modulation |
|
| ALT_DEFINITION |
A drug usually used to treat stomach ulcers and heartburn. It is also commonly used in a regimen to prevent allergic reactions. |
|
| CAS_Registry |
51481-61-9 |
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| CHEBI_ID |
CHEBI:3699 |
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| Chemical_Formula |
C10H16N6S |
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| code |
C374 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine's ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor. (NCI04) |
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| Display_Name |
Cimetidine |
|
| FDA_UNII_Code |
80061L1WGD |
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| FULL_SYN |
N-Cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine Guanidine, N''-Cyano-N-Methyl-N'-(2-(((5-Methyl-1H-Imidazol-4-yl)Methyl)Thio)Ethyl)- CIMETIDINE Cimetidine Tagamet cimetidine |
|
| Has_Salt_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Cimetidine |
|
| Legacy Concept Name |
Cimetidine |
|
| Maps_To |
Cimetidine |
|
| NCI_Drug_Dictionary_ID |
39185 |
|
| NSC Number |
335308 |
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| PDQ_Closed_Trial_Search_ID |
39185 |
|
| PDQ_Open_Trial_Search_ID |
39185 |
|
| Preferred_Name |
Cimetidine |
|
| prefixIRI |
Thesaurus:C374 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0008783 |
|
| subClassOf |