National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Chloramphenicol
Synonyms

CHLORAMPHENICOL

[R-(R*,R*)]-2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide

Chloramphenicol

Definitions

A semisynthetic, broad-spectrum antibiotic derived from Streptomyces venequelae with primarily bacteriostatic activity. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit. The binding interferes with peptidyl transferase activity, thereby prevents transfer of amino acids to the growing peptide chains and blocks peptide bond formation. As a result bacterial protein synthesis is blocked and impede bacterial cell proliferation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C363

CAS_Registry

56-75-7

CHEBI_ID

CHEBI:17698

Chemical_Formula

C11H12Cl2N2O5

code

C363

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A semisynthetic, broad-spectrum antibiotic derived from Streptomyces venequelae with primarily bacteriostatic activity. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit. The binding interferes with peptidyl transferase activity, thereby prevents transfer of amino acids to the growing peptide chains and blocks peptide bond formation. As a result bacterial protein synthesis is blocked and impede bacterial cell proliferation.

FDA_UNII_Code

66974FR9Q1

FULL_SYN

CHLORAMPHENICOL

[R-(R*,R*)]-2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide

Chloramphenicol

label

Chloramphenicol

Legacy Concept Name

Chloramphenicol

NSC Number

3069

Preferred_Name

Chloramphenicol

prefixIRI

Thesaurus:C363

Semantic_Type

Organic Chemical

Pharmacologic Substance

Antibiotic

UMLS_CUI

C0008168

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C258

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C784

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/OGCO_00000448 OGCO LOOM
http://purl.bioontology.org/ontology/CSP/0194-6047 CRISP LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 FYPO LOOM
http://purl.obolibrary.org/obo/XCO_0001139 XCO LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 CHEBI LOOM
http://purl.obolibrary.org/obo/ARO_3000385 ARO LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 DRON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.455.706.300 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.565.175 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002701 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/J01BA01 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372777009 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.640.529.175 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015746 PMAPP-PMO LOOM
http://purl.jp/bio/10/gmo/GMO_001347 GMO LOOM
http://purl.bioontology.org/ontology/VANDF/4018199 VANDF LOOM
http://purl.obolibrary.org/obo/NCIT_C363 BERO LOOM
http://stirdf.jst.go.jp/id/200907075954773647 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/S01AA01 ATC LOOM
http://purl.bioontology.org/ontology/LNC/LP15321-0 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/2348 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2814 OCHV LOOM
https://go.drugbank.com/drugs/DB00446 MDM LOOM
http://purl.bioontology.org/ontology/MESH/D002701 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0008168 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4021527 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 CIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 ECTO LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 MCO LOOM
http://purl.obolibrary.org/obo/CHEBI_17698 EFO LOOM
http://www.drugbank.ca/drugs/DB00446 FTC LOOM
http://purl.bioontology.org/ontology/ATC/S02AA01 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004842 LOINC LOOM
http://purl.bioontology.org/ontology/RCD/XM0lE RCD LOOM
http://purl.obolibrary.org/obo/OMIT_0004025 OMIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146533 NDFRT LOOM
http://purl.bioontology.org/ontology/ATC/D06AX02 ATC LOOM
http://purl.bioontology.org/ontology/ATC/G01AA05 ATC LOOM
http://purl.bioontology.org/ontology/CPT/82415 CPT LOOM
http://purl.bioontology.org/ontology/ATC/D10AF03 ATC LOOM
http://www.co-ode.org/ontologies/galen#Chloramphenicol GALEN LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Chloramphenicol SEPON LOOM
http://purl.jp/bio/4/id/200906010165232935 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/S03AA08 ATC LOOM
http://localhost/plosthes.2017-1#258 PLOSTHES LOOM
http://purl.bioontology.org/ontology/CSP/0194-6047 CRISP LOOM
http://purl.obolibrary.org/obo/MESH_D002701 BERO LOOM

Notes

Filter:
Delete Subject Subject Sort Archive Sort Author Type Class Created
New concept - total skin sparing mastectomy     New concept - total skin sparing mastectomy false anonymous Comment http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15277 2013-05-22
causes and symptoms     causes and symptoms false linairis Comment 2009-08-06
Test note     Test note false decorons Comment 2011-02-07
    false decorons Comment 2008-12-31
An image example for melanoma     An image example for melanoma false jonquet Comment 2008-08-06
    false decorons Comment 2008-12-31
    false decorons Comment 2008-12-31
Wikipedia page on 'melanoma'     Wikipedia page on 'melanoma' false jonquet Comment 2008-08-06
Antineoplastic antibiotics are antibiotics (?)     Antineoplastic antibiotics are antibiotics (?) false coulet Comment 2013-01-25
New Term Proposal: abcd     New Term Proposal: abcd false fergerson New Class Proposal 2010-12-17
NIH-What Causes COPD     NIH-What Causes COPD false linairis Comment 2009-08-06
The treatment of COPD     The treatment of COPD false linairis Comment 2009-08-06
relationship with Smoking Behavior     relationship with Smoking Behavior false pkcourtney Comment 2010-06-22
RE: Antineoplastic antibiotics are antibiotics (?)     RE: Antineoplastic antibiotics are antibiotics (?) false rwynne Comment 2013-02-13
    false decorons Comment 2008-12-31
MedlinePlus     MedlinePlus false linairis Comment 2009-08-06
/ontologies/NCIT/notes/https%3A%2F%2Fdata.bioontology.org%2Fnotes%2F8dfd5db0-bd90-0136-3c5b-005056010073     false tabasco_tabata%40yahoo.co.jp Comment 2018-10-29
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