loading...| Preferred Name | Multiple Endocrine Neoplasia Type 1 | |
| Synonyms |
Wermer syndrome Wermer Syndrome Wermer's Syndrome Multiple Endocrine Neoplasia, Type I multiple endocrine neoplasia type 1 syndrome Multiple Endocrine Neoplasia Type I Multiple Endocrine Neoplasia Type 1 Multiple endocrine neoplasia [MEN] type I Multiple Endocrine Adenomatosis MEN1 syndrome Multiple Endocrine Adenomatosis, Type I Multiple Endocrine Adenomatosis Type 1 Multiple Endocrine Adenomatosis Type I MEA Type 1 MEA Type I MEN 1 MEN Type 1 MEN Type I |
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| Definitions |
Multiple endocrine neoplasia caused by inactivation of the tumor suppressor gene MEN-1. Patients may develop hyperparathyroidism and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell neoplasms, and carcinoid tumors. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3225 |
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| ALT_DEFINITION |
A rare, inherited disorder that affects the endocrine glands and can cause tumors in the parathyroid and pituitary glands and the pancreas. These tumors are usually benign (not cancer). They cause the glands to secrete high levels of hormones, which can lead to other medical problems, such as kidney stones, fertility problems, and severe ulcers. In some cases, tumors inside the pancreas can become malignant (cancer). Multiple endocrine neoplasia caused by inactivating mutation(s) of the tumor suppressor gene MEN1, encoding the menin protein, a component of the histone methyltransferase complex. The condition is characterized by hyperfunctioning adenomas of the parathyroid glands, adrenal glands, pituitary gland, and pancreatic endocrine cells (most commonly gastrinomas and insulinomas); thymic and bronchial carcinoid tumors also may develop. |
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| code |
C3225 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177281 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118467 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177516 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192842 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118168 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C165258 |
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| Contributing_Source |
Cellosaurus CCPS CTRP NICHD mCode |
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| DEFINITION |
Multiple endocrine neoplasia caused by inactivation of the tumor suppressor gene MEN-1. Patients may develop hyperparathyroidism and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell neoplasms, and carcinoid tumors. |
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| Display_Name |
Multiple Endocrine Neoplasia Type 1 |
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| FULL_SYN |
Wermer syndrome Wermer Syndrome Wermer's Syndrome Multiple Endocrine Neoplasia, Type I multiple endocrine neoplasia type 1 syndrome Multiple Endocrine Neoplasia Type I Multiple Endocrine Neoplasia Type 1 Multiple endocrine neoplasia [MEN] type I Multiple Endocrine Adenomatosis MEN1 syndrome Multiple Endocrine Adenomatosis, Type I Multiple Endocrine Adenomatosis Type 1 Multiple Endocrine Adenomatosis Type I MEA Type 1 MEA Type I MEN 1 MEN Type 1 MEN Type I |
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| label |
Multiple Endocrine Neoplasia Type 1 |
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| Legacy Concept Name |
Multiple_Endocrine_Neoplasia_Type_I |
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| Neoplastic_Status |
Undetermined |
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| Preferred_Name |
Multiple Endocrine Neoplasia Type 1 |
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| prefixIRI |
Thesaurus:C3225 |
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| Related_To_Genetic_Biomarker | ||
| Semantic_Type |
Neoplastic Process |
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| UMLS_CUI |
C0025267 |
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| subClassOf |