loading...| Preferred Name |
Langerhans Cell Histiocytosis |
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| Synonyms |
Langerhans cell granulomatosis Langerhans Cell Histiocytosis Histiocytosis X Langerhans cell histiocytosis, NOS Langerhans cell histiocytosis Langerhans Cell Granulomatosis LCH |
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| Definitions |
A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. The clinical course is generally related to the number of organs affected at presentation. (WHO, 2001) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3107 |
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| ALT_DEFINITION |
Tissue infiltration by Langerhans cells (histiocytes). When infiltration involves the pituitary stalk or gland, presentation includes diabetes insipidus, which is sometimes accompanied by other pituitary dysfunction. A group of rare disorders in which too many Langerhans cells (a type of white blood cell) grow in certain tissues and organs including the bones, skin, and lungs, and damage them. Langerhans cell histiocytosis may also affect the pituitary gland (which makes hormones that control other glands and many body functions, especially growth). Langerhans cell histiocytosis is most common in children and young adults. |
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| code |
C3107 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168661 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168656 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168662 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118467 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168658 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192842 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126659 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118168 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C165258 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102905 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103078 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168655 |
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| Contributing_Source |
Cellosaurus CTEP CTRP GDC NICHD |
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| DEFINITION |
A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. The clinical course is generally related to the number of organs affected at presentation. (WHO, 2001) |
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| Display_Name |
Langerhans Cell Histiocytosis |
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| FULL_SYN |
Langerhans cell granulomatosis Langerhans Cell Histiocytosis Histiocytosis X Langerhans cell histiocytosis, NOS Langerhans cell histiocytosis Langerhans Cell Granulomatosis LCH |
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| ICD-O-3_Code |
9751/1 9751/3 9752/1 9753/1 9754/3 |
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| Is_Value_For_GDC_Property | ||
| label |
Langerhans Cell Histiocytosis |
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| Legacy Concept Name |
Langerhans_Cell_Histiocytosis |
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| Maps_To |
Langerhans cell granulomatosis Langerhans cell histiocytosis, NOS Histiocytosis X, NOS 9751/1 9751/3 |
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| Neoplastic_Status |
Undetermined |
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| Preferred_Name |
Langerhans Cell Histiocytosis |
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| prefixIRI |
Thesaurus:C3107 |
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| Semantic_Type |
Neoplastic Process |
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| UMLS_CUI |
C0019621 |
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| subClassOf |