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National Cancer Institute Thesaurus
| Preferred Name | Rabeprazole | |
| Synonyms |
2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole Rabeprazole RABEPRAZOLE LY307640 |
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| Definitions |
An alpha-pyridylmethylsulfinyl benzimidazole and a selective and irreversible proton pump inhibitor with antisecretory property. Rabeprazole enters the parietal cell and accumulates in the acidic secretory canaliculi where the agent is activated by a proton-catalyzed process that results in the formation of a thiophilic sulfonamide or sulfenic acid. The activated rabeprazole forms covalent bonds with the sulfhydryl amino acids cysteine on the extracellular domain of the proton pump (H+/K+ ATPase) at the secretory surface, thereby inhibiting the transport of hydrogen ions, via exchange with potassium ions, into the gastric lumen. Binding to cysteine 813, in particular, is essential for inhibition of gastric acid production. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29410 |
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| CAS_Registry |
117976-89-3
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| CHEBI_ID |
CHEBI:8768
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| Chemical_Formula |
C18H21N3O3S
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|
| code |
C29410
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
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| Contributing_Source |
FDA HemOnc
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| DEFINITION |
An alpha-pyridylmethylsulfinyl benzimidazole and a selective and irreversible proton pump inhibitor with antisecretory property. Rabeprazole enters the parietal cell and accumulates in the acidic secretory canaliculi where the agent is activated by a proton-catalyzed process that results in the formation of a thiophilic sulfonamide or sulfenic acid. The activated rabeprazole forms covalent bonds with the sulfhydryl amino acids cysteine on the extracellular domain of the proton pump (H+/K+ ATPase) at the secretory surface, thereby inhibiting the transport of hydrogen ions, via exchange with potassium ions, into the gastric lumen. Binding to cysteine 813, in particular, is essential for inhibition of gastric acid production.
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| FDA_UNII_Code |
32828355LL
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| FULL_SYN |
2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole Rabeprazole RABEPRAZOLE LY307640
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|
| Has_Salt_Form | ||
| label |
Rabeprazole
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|
| Legacy Concept Name |
Rabeprazole
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| NCI_Drug_Dictionary_ID |
641009
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| PDQ_Closed_Trial_Search_ID |
641009
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| PDQ_Open_Trial_Search_ID |
641009
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| Preferred_Name |
Rabeprazole
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|
| prefixIRI |
Thesaurus:C29410
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0378482
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| subClassOf |
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