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National Cancer Institute Thesaurus
| Preferred Name | Nitroglycerin | |
| Synonyms |
NITROGLYCERIN Nitroglycerin nitroglycerin Rectiv |
|
| Definitions |
An organic nitrate with vasodilator activity. Nitroglycerin is converted into nitric oxide (NO) in smooth muscle and activates guanylyl cyclase, thereby increasing cGMP concentration, and resulting in smooth muscle relaxation. Dilatation of the veins results in decreased venous return to the heart, thereby decreasing left ventricular volume (reduced preload) and decreasing myocardial oxygen requirements. Arteriolar relaxation reduces arteriolar resistance (reduced afterload), thereby decreasing myocardial oxygen demands. In addition, nitroglycerine causes coronary artery dilatation, thereby improving myocardial blood distribution. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29294 |
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| Accepted_Therapeutic_Use_For |
Anal Fissure and Fistula
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| ALT_DEFINITION |
In medicine, a substance used as a drug to treat certain heart conditions and to widen the openings in blood vessels. Nitroglycerin is being studied as a way to help chemotherapy work better by making tumor cells more sensitive to the drugs. It is a type of vasodilator.
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| CAS_Registry |
55-63-0
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| CHEBI_ID |
CHEBI:28787
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| Chemical_Formula |
C3H5N3O9
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|
| code |
C29294
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
An organic nitrate with vasodilator activity. Nitroglycerin is converted into nitric oxide (NO) in smooth muscle and activates guanylyl cyclase, thereby increasing cGMP concentration, and resulting in smooth muscle relaxation. Dilatation of the veins results in decreased venous return to the heart, thereby decreasing left ventricular volume (reduced preload) and decreasing myocardial oxygen requirements. Arteriolar relaxation reduces arteriolar resistance (reduced afterload), thereby decreasing myocardial oxygen demands. In addition, nitroglycerine causes coronary artery dilatation, thereby improving myocardial blood distribution.
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|
| Display_Name |
Nitroglycerin
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|
| FDA_UNII_Code |
G59M7S0WS3
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| FULL_SYN |
NITROGLYCERIN Nitroglycerin nitroglycerin Rectiv
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|
| label |
Nitroglycerin
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|
| Legacy Concept Name |
Nitroglycerin
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| NCI_Drug_Dictionary_ID |
587505
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| PDQ_Closed_Trial_Search_ID |
587505
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| PDQ_Open_Trial_Search_ID |
587505
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| Preferred_Name |
Nitroglycerin
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| prefixIRI |
Thesaurus:C29294
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|
| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0017887
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| subClassOf |
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