National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Neural Cell Adhesion Molecule 1
Synonyms

Neural Cell Adhesion Molecule

Antigen MSK39 Identified By Monoclonal Antibody 5.1H11

Neural Cell Adhesion Molecule 1

CD56 Antigen

CD56

N-CAM-1

NCAM

NCAM-1

NCAM1

NKH-1

Definitions

Neural cell adhesion molecule 1 (761 aa, ~84 kDa) is encoded by the human NCAM1 gene. This protein is involved in the mediation of neuron-neuron adhesion.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25276

code

C25276

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

GDC

DEFINITION

Neural cell adhesion molecule 1 (761 aa, ~84 kDa) is encoded by the human NCAM1 gene. This protein is involved in the mediation of neuron-neuron adhesion.

DesignNote

Neural Cell Adhesion Molecule is a membrane-bound glycoprotein member of the Ig superfamily that binds to a variety of other cell adhesion proteins involved in diverse contact-mediated interactions. NCAM appears on early embryonic cells and is important in the formation of cell collectives at sites of morphogenesis. Later it is found on differentiated neurons, astrocytes, oligodendrocytes, and myotubes and mediates neuronal adhesion, guidance, and differentiation. NCAM plays a role in cell-cell and cell-matrix adhesion through homophilic and heterophilic binding. The invertebrate cell adhesion molecules fasciclin II (grasshoppers and Drosophila) and apCAM (Aplysia) are related to NCAM and can mediate homophilic cell aggregation. Four main isoforms exist, including CD56, but many variants result from alternative splicing and post-translational modifications.

Display_Name

Neural Cell Adhesion Molecule 1

FULL_SYN

Neural Cell Adhesion Molecule

Antigen MSK39 Identified By Monoclonal Antibody 5.1H11

Neural Cell Adhesion Molecule 1

CD56 Antigen

CD56

N-CAM-1

NCAM

NCAM-1

NCAM1

NKH-1

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C268

label

Neural Cell Adhesion Molecule 1

Legacy Concept Name

Neural_Cell_Adhesion_Molecule

Maps_To

CD56

OMIM_Number

116930

Preferred_Name

Neural Cell Adhesion Molecule 1

prefixIRI

Thesaurus:C25276

Semantic_Type

Amino Acid, Peptide, or Protein

Swiss_Prot

P13591

UMLS_CUI

C1999531

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16393

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