loading...| Preferred Name |
Aminopterin |
|
| Synonyms |
Aminopterin 4-Aminopteroyl-glutamic Acid 4-Aminopteroylglutamic acid Aminopteroylglutamic Acid AMINOPTERIN aminopterin 4-Aminofolic acid 4-Aminofolic Acid 4-Aminopteroylglutamic Acid 4-Amino-PGA APGA |
|
| Definitions |
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C235 |
|
| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called antimetabolites. |
|
| CAS_Registry |
54-62-6 |
|
| CHEBI_ID |
CHEBI:22526 |
|
| Chemical_Formula |
C19H20N8O5 |
|
| code |
C235 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC HemOnc |
|
| DEFINITION |
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04) |
|
| FDA_UNII_Code |
JYB41CTM2Q |
|
| FULL_SYN |
Aminopterin 4-Aminopteroyl-glutamic Acid 4-Aminopteroylglutamic acid Aminopteroylglutamic Acid AMINOPTERIN aminopterin 4-Aminofolic acid 4-Aminofolic Acid 4-Aminopteroylglutamic Acid 4-Amino-PGA APGA |
|
| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Aminopterin |
|
| Legacy Concept Name |
Aminopterin |
|
| Maps_To |
Aminopterin |
|
| NCI_Drug_Dictionary_ID |
39141 |
|
| NSC Number |
739 |
|
| PDQ_Closed_Trial_Search_ID |
39141 |
|
| PDQ_Open_Trial_Search_ID |
39141 |
|
| Preferred_Name |
Aminopterin |
|
| prefixIRI |
Thesaurus:C235 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0002583 |
|
| subClassOf |