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National Cancer Institute Thesaurus
| Preferred Name | Sodium Butyrate | |
| Synonyms |
Sodium butyrate sodium butanoate SODIUM BUTYRATE Butyric Acid, Sodium Salt Sodium Butyrate butyric acid, sodium salt Butyrate sodium Sodium butanoate Butyrate |
|
| Definitions |
The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2337 |
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| CAS_Registry |
156-54-7
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|
| CHEBI_ID |
CHEBI:64103
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| Chemical_Formula |
C4H7O2.Na
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|
| code |
C2337
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
FDA GDC
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|
| DEFINITION |
The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling.
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|
| FDA_UNII_Code |
8RAS91C36W
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|
| FULL_SYN |
Sodium butyrate sodium butanoate SODIUM BUTYRATE Butyric Acid, Sodium Salt Sodium Butyrate butyric acid, sodium salt Butyrate sodium Sodium butanoate Butyrate
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| Is_Value_For_GDC_Property | ||
| label |
Sodium Butyrate
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|
| Legacy Concept Name |
Sodium_Butyrate
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|
| Maps_To |
Sodium Butyrate
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| NCI_Drug_Dictionary_ID |
39601
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|
| NSC Number |
174280
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|
| PDQ_Closed_Trial_Search_ID |
39601
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|
| PDQ_Open_Trial_Search_ID |
39601
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|
| Preferred_Name |
Sodium Butyrate
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|
| prefixIRI |
Thesaurus:C2337
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0142812
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| subClassOf |
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