loading...| Preferred Name |
Topoisomerase-II Inhibitor |
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| Synonyms |
Topoisomerase-II Inhibitor Topoisomerase-II Inhibitors |
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| Definitions |
Any substance that inhibits topoisomerase-II, a topoisomerase that relieves torsional stress in a DNA molecule by cutting both strands of the DNA double helix. A topoisomerase II inhibitor can either stabilize the DNA-protein complex or inhibit the catalytic activity of the enzyme. Inhibition of topoisomerase-II causes DNA damage, inhibition of DNA replication, and apoptosis. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1968 |
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| CHEBI_ID |
CHEBI:50750 |
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| code |
C1968 |
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| DEFINITION |
Any substance that inhibits topoisomerase-II, a topoisomerase that relieves torsional stress in a DNA molecule by cutting both strands of the DNA double helix. A topoisomerase II inhibitor can either stabilize the DNA-protein complex or inhibit the catalytic activity of the enzyme. Inhibition of topoisomerase-II causes DNA damage, inhibition of DNA replication, and apoptosis. |
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| FULL_SYN |
Topoisomerase-II Inhibitor Topoisomerase-II Inhibitors |
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| label |
Topoisomerase-II Inhibitor |
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| Legacy Concept Name |
Topoisomerase-II_Inhibitor |
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| Preferred_Name |
Topoisomerase-II Inhibitor |
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| prefixIRI |
Thesaurus:C1968 |
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| Semantic_Type |
Chemical Viewed Functionally |
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| UMLS_CUI |
C1519554 |
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| subClassOf |