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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1748
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1748
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|---|---|
| Preferred Name | Topoisomerase Inhibitor |
| Definitions |
Any substance that inhibits topoisomerase, an enzyme that cleaves the DNA backbone to relieve torsional stress in a DNA molecule generated during replication, transcription, and other structural transformations. Inhibition of topoisomerase causes DNA damage, inhibition of DNA replication, and apoptosis.
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| Synonyms |
topoisomerase inhibitor
Topoisomerase Inhibitors
Topoisomerase Inhibitor
DNA Topoisomerase Inhibitors
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Topoisomerase Inhibitor
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|---|---|
| Legacy Concept Name |
Topoisomerase_Inhibitor
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| Preferred_Name |
Topoisomerase Inhibitor
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| Semantic_Type |
Chemical Viewed Functionally
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| prefixIRI |
Thesaurus:C1748
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| DEFINITION |
Any substance that inhibits topoisomerase, an enzyme that cleaves the DNA backbone to relieve torsional stress in a DNA molecule generated during replication, transcription, and other structural transformations. Inhibition of topoisomerase causes DNA damage, inhibition of DNA replication, and apoptosis.
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| UMLS_CUI |
C0598317
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| code |
C1748
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| subClassOf | |
| type | |
| FULL_SYN |
topoisomerase inhibitor
Topoisomerase Inhibitors
Topoisomerase Inhibitor
DNA Topoisomerase Inhibitors
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| ALT_DEFINITION |
A substance that blocks topoisomerases (enzymes that break and rejoin DNA strands and are needed for cells to divide and grow). Blocking these enzymes may kill cancer cells. Certain topoisomerase inhibitors are being studied in the treatment of cancer.
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