National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Tyrosine Kinase Inhibitor
Synonyms

Protein Tyrosine Kinase Inhibitors

Tyrosine Kinase Inhibitor

tyrosine kinase inhibitor

TK Inhibitors

PTK Inhibitors

Definitions

Any substance that inhibits tyrosine kinase, an enzyme involved in the transduction and processing of many extracellular and intracellular signals including cell proliferation. Inhibition of tyrosine kinase may result in inhibition of cell growth and cell proliferation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1967

ALT_DEFINITION

A drug that interferes with cell communication and growth and may prevent tumor growth. Some tyrosine kinase inhibitors are used to treat cancer.

CHEBI_ID

CHEBI:38637

code

C1967

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

GDC

DEFINITION

Any substance that inhibits tyrosine kinase, an enzyme involved in the transduction and processing of many extracellular and intracellular signals including cell proliferation. Inhibition of tyrosine kinase may result in inhibition of cell growth and cell proliferation.

Display_Name

Tyrosine Kinase Inhibitor

FULL_SYN

Protein Tyrosine Kinase Inhibitors

Tyrosine Kinase Inhibitor

tyrosine kinase inhibitor

TK Inhibitors

PTK Inhibitors

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Tyrosine Kinase Inhibitor

Legacy Concept Name

Tyrosine_Kinase_Inhibitor

Maps_To

Tyrosine Kinase Inhibitor

Preferred_Name

Tyrosine Kinase Inhibitor

prefixIRI

Thesaurus:C1967

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C1268567

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1404

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