C17373

CTRP

Integrin alpha-M (1152 aa, ~127 kDa) is encoded by the human ITGAM gene. This protein is involved in both leukocyte adhesion and the phagocytosis of complement coated particles.

An adhesion-promoting leukocyte surface integrin heterodimer contains an alpha subunit of CD11b antigen and a beta subunit of CD18 antigen. The heterodimer functions as a receptor for complement 3, and in cell-cell and cell-substrate adhesive interactions. Major surface antigens on leukocytes include CR3A, LFA-1, and p150,95, which share a common beta chain linked to one of three alpha distinctive chains. They promote adhesion of granulocytes to each other and to endothelial cells. The CR3A alpha subunit (CD11b) is homologous to the alpha subunit of IIb/IIIa, a platelet glycoprotein that also serves adhesive functions. CD11b also exhibits significant homology with portions of the alpha subunits of fibronectin, vitronectin, platelet IIb/IIIa receptors, and p150,95. The protein consists of an N-terminal extracytoplasmic domain, a transmembrane segment, and a short C-terminal cytoplasmic domain.

Integrin Alpha-M

CR-3 Alpha Chain

CD11 Antigen-Like Family Member B

Integrin Alpha-M

Integrin Alpha M

Neutrophil Adherence Receptor

Neutrophil Adherence Receptor Alpha-M Subunit

Cell Surface Glycoprotein MAC-1 Subunit Alpha

Leukocyte Adhesion Receptor MO1

Macrophage Antigen Alpha Polypeptide

Complement Receptor Type 3, Alpha Subunit

CD11b Antigen

CD11b

ITGAM

MAC1 Alpha

MO1 Alpha

Integrin Alpha-M

Integrin_Alpha-M

120980

Integrin Alpha-M

Thesaurus:C17373

Amino Acid, Peptide, or Protein

P11215

C1701032